IHEM 20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
artículos
Título:
Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor
Autor/es:
SÁNCHEZ, MARÍA CECILIA; FADER, CLAUDIO MARCELO; CALDARONE, PAULA VIRGINIA SUBIRADA; COLOMBO, MA?IA ISABEL; GROSSO, RUBEN ADRIAN; CHIABRANDO, GUSTAVO ALBERTO
Revista:
BIOSCIENCE REPORTS
Editorial:
PORTLAND PRESS LTD
Referencias:
Lugar: Londres; Año: 2019 vol. 39
ISSN:
0144-8463
Resumen:
Hemin is an erythropoietic inductor capable of inducing autophagy in erythroid-like cell lines. Low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor involved in a wide range of cellular processes, such as proliferation, differentiation, and metabolism. Our aim was to evaluate whether LRP1 is responsible for hemin activity in K562 cells, with the results demonstrating a three-fold increase in LRP1 gene expression levels (P-values
