CONICET | Buscador de Institutos y Recursos Humanos

Coxiella burnetii, the causative agent of Q fever, is an obligate intracellularpathogen that causes acute and chronic infections. In this brief review, we describe how recent advances have improved our understanding of C. burnetii invasion and host cell modulation, including the formation of a replicative niche: the Coxiella-containing vacuole. We describe the actin-associated proteins involved in the internalization of C. burnetii, and we discuss the contribution of different degradative pathway of the cell during the formation and stabilization of the Coxiella-containing vacuole.