IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
artículos
Título:
Administration of Noradrenaline in the Autonomic Ganglia Modifies the Testosterone Release from the Testis using an ex vivo System
Autor/es:
SOSA, ZULEMA Y.; PALMADA, MIGUEL N.; FÓSCOLO, MABEL R.; CONILL, ALBERTO; CAVICCHIA, JUAN CARLOS
Revista:
International Journal of Andrology
Editorial:
Blackwell Science Ltd.
Referencias:
Lugar: Finland; Año: 2009 vol. 32 p. 391 - 398
ISSN:
0105-6263
Resumen:
Summary
The male gonad receives nerve fibres from the autonomic ganglionic system.
These fibres converge on the testis along two pathways, the superior and the
inferior spermatic nerves. The superior spermatic nerve runs from the superior
mesenteric ganglion alongside the testicular artery, whereas the inferior spermatic
nerve originates in inferior mesenteric ganglion, accompanies the vas deferens
and penetrates the inferior pole of the testis. The aim of this work was to
evaluate androgen release after the addition of noradrenaline or adrenoreceptor
antagonists (propranolol or phentolamine) to the ganglionic compartment. An
ex vivo system used in a previous work was incubated in two separate containers,
one for the testis and the other for the ganglion. Both organs remain interconnected
(as in vivo) by the respective spermatic nerve. When noradrenaline
was added to the inferior mesenteric ganglion, testosterone release in the gonad
container underwent a progressive and significant increment. Propranolol
diminishes and phentolamine increases the androgen release. When using the
superior mesenteric ganglion, no changes were observed. These results indicate
that the ganglionic stimulation of the autonomic system clearly participates in
testosterone release from the testis. This effect depends on the ganglion
involved. These results make it evident that not only the classical and wellknown
hypothalamushypophysial axis, but also the peripheral nervous system,
via the autonomic ganglia, are directly involved in the endocrine control of the
testis