IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
artículos
Título:
Effect of dehydroleucodine on the reproductive tract of male mice
Autor/es:
SHUHAIMAN L; DE ROSAS J.C; SARTOR T; PALMADA N; GIORDANO O.S; LOPEZ L.A.
Revista:
ANDROLOGIA
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Giessen, Alemania; Año: 2009
ISSN:
0303-4569
Resumen:
Summary
The effects of a sesquiterpene lactone, dehydroleucodine, on the reproductive tract
were investigated using adult male mice. Dehydroleucodine was dissolved in tap
water and administered as drinking water for 30 days. All the parameters were
compared to a control group that received only vehicle. Animals were killed by
decapitation and the trunk blood, the testes and the epididymis were collected.
Plasma concentrations of testosterone and estradiol, and testicular weight and
concentration of spermatids did not change by dehydroleucodine. Nevertheless, in
epididymal cauda dehydroleucodine treatment caused a diminution in sperm
number, a decrease in the amount of tubular fluid and a reduction in the activity of
the hydrolytic enzyme N-acetyl- â-D-glucosaminidase. However, the sperm
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.
â-D-glucosaminidase. However, the sperm
motility was not altered by dehydroleucodine treatment, although sperm binding
to zona-free oocytes increased significantly. These results suggest that
dehydroleucodine, which has been implicated in the inhibition of aromatase P450,
does not affect the plasma concentration of testosterone and estradiol or testicular
activity, while altering several epidydimal parameters. The epididymis is thus a
more sensitive target for dehydroleucodine action.