IHEM 20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
artículos
Título:
Goligi-associated Rab14, a new regulator for Chlamydia trachomatis infection outcome
Autor/es:
CAPMANY A; LEIVA N; DAMIANI MT
Revista:
Communicative & integrative biology
Editorial:
Landes Bioscience
Referencias:
Lugar: Austin, TX; Año: 2011 vol. 4 p. 590 - 593
ISSN:
1942-0889
Resumen:
Chlamydia trachomatis is the causingagent of the most frequent bacterialsexually-transmitted diseases worldwideand is an underlying cause of chronicpelvic inflammatory diseases and cervicalcancer. It is an obligate intracellularbacterium that establishes a close relationshipwith the Golgi complex andparasites the biosynthetic machinery ofhost cells. In a recent study, we have demonstratedthat Rab14, a newly-describedGolgi-associated Rab, is involved in thedelivery of sphingolipids to the growingbacteria-containing vacuole. Theinterference with Rab14-controlledtrafficking pathways delays chlamydialinclusion enlargement, decreases bacteriallipid uptake, negatively impact onbacterial differentiation, and reducesbacterial progeny and infectivity.C. trachomatis manipulation of host traffickingpathways for the acquisition ofendogenously-biosynthesized nutrientsarises as one of the characteristics of thishighly evolved pathogen. The developmentof therapeutic strategies targeted tointerfere with bacterium-host cell interactionis a new challenge for pharmacologicalapproaches to control chlamydialinfections.
