IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
artículos
Título:
Editorial: New Roles of Autophagy Pathways in Cancer
Autor/es:
FADER, CLAUDIO M.; MORSELLI, EUGENIA; MARTINS, WALESKA K.; GRASSO, DANIEL
Revista:
Frontiers in Oncology
Editorial:
Frontiers Media S.A.
Referencias:
Lugar: Lausanne; Año: 2021 vol. 11
Resumen:
From a simplistic point of view, autophagy is a self-degradative process that relies on lysosomes forthe removal of cytoplasmic bulk cargo and damaged organelles, such as mitochondria. Further on itshomeostatic role, autophagy acts as a catabolic process that promotes cellular resilience inconditions of nutrient deprivation and energy depletion. A body of literature has established acrucial role of autophagy in a whole plethora of different physiological processes ranging fromhomeostasis maintenance, development, and differentiation, among others. In the last two decades,the complexity of autophagy regulation has grown exponentially. Indeed, the literature recognizescanonical and non-canonical autophagic pathways that lead to the degradation and clearance ofnon-specific or specific cargos (selective autophagy) depending on the cellular context. Due to thefundamental role of autophagy in homeostasis maintenance, it is not surprising its recognizedetiologic role in age-related diseases, including cancer. In cancer, autophagy has a dual function,acting as a cell survival mechanism (e.g. favoring the growth of established tumors) or as a tumorsuppressor (e.g. preventing the accumulation of damaged proteins and organelles). Thus, therelationship of autophagy with carcinogenesis is complex and, in most cases, it is considered acontext-dependent process.