Tracking Control of Optimal Profiles in a Nonlinear Fed-Batch Bioprocess under Parametric Uncertainty and Process Disturbances.

PANTANO, MARÍA NADIA; FERNANDEZ, MARÍA CECILIA; SERRANO, MARIO EMANUEL; ORTIZ, OSCAR ALBERTO; SCAGLIA, GUSTAVO J. E.

INDUSTRIAL & ENGINEERING CHEMICAL RESEARCH

AMER CHEMICAL SOC

Año: 2018

0888-5885

The problem of optimal profiles tracking control under uncertainties for a nonlinear fed-batch bioprocess is addressed in this paper. Based on the results reported in,1 this work aims to improve the control system response against parametric uncertainty and process disturbances. The methodology is simple, easy to implement, but with excellent results. The design parameters are optimized by a randomized Montecarlo algorithm. Besides, demonstration of the tracking error convergence to zero when the system is subjected to uncertainties is included in the article. The control system performance is tested through simulations, showing the improvement achieved.