Polyvinyl Alcohol–Pectin Cryogel Films for Controlled Release of Enrofloxacin

MARTINEZ YANINA; PIÑUEL LUCRECIA; CASTRO GUILLERMO; BRECCIA JAVIER D.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

HUMANA PRESS INC

Lugar: Oregon; Año: 2012 vol. 167 p. 421 - 429

0273-2289

The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel atpH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C.In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was addedinto the cryogel (PVA–P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacinreleased only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showedthat most of the interactions between PVA–P matrix and enrofloxacin were due to polargroups (carboxylate and amine), a two-layer film system was designed to modulate thereleasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacinwas found dependent on NaCl concentration in the upper gel layer. The two-layer cryogelsystem showed attractive features for transcutaneous antibiotic delivery.