CELIAC DISEASE: ADHERENCE TO GLUTEN FREE DIET AND ROLE OF ANTIBODIES

ZIALLORENZO, PAULA; DI MAURO, PAULA; MOTTA, ESTELA; CHISARI, ANDREA

Leipzig, Germany

Congreso; 10th International Congress on Autoimmunity; 2016

Royal Society of Chemistry

Gluten free diet (GFD) is the common treatment of celiac disease (CD). Despite this treatment, it can be difficult to completely avoid gluten. The aims of this study were to assess the factors that may influence the adherence to GFD and to study the role of antibodies in assessing adherence to GFD in adult CD. Methods: Adults diagnosed with biopsy confirmed CD for longer than one year participated in this study and followed by completion of a questionnaire and had blood drawn for IgA and IgG anti tissue transglutaminase (tTG) antibody titer and immunoglobulin A (IgA) level. Results: Thirty three patients participated, the mean age was 46. 85 +/- 16.04 year. The study population was found to adhere well to a GFD, with 72.7% being rated as high adherent; 30.3 % of participants answered that the small bid of gluten-free foods in some places caused transgressions to the diet. After a year of gluten-free diet, antibodies were poor predictors of dietary transgressions (RR: 1.91, 90 % CI: 0.84-4.36) while after five years of GFD, antibodies tTG resulted in good predictors of dietary transgressions (RR: 3.67; 90% CI: 1.05-12.82). The sensitivity of IgA tTG ab depends on the duration of compliance to the diet (70.8 % vs 100 %, overall and more than 5 yr respectively). Conclusions: The adherence to diet is associated with some factors. In these CD patients, the role of antibodies as predictors of high adherence to diet depends on the length of compliance to GFD