IIB 20738
INSTITUTO DE INVESTIGACIONES BIOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
Regulation of lipid peroxidation and ferroptosis in diverse species
Autor/es:
HÜLYA BAYIR; MARET G. TRABER; MARCUS CONRAD; GABRIELA C. PAGNUSSAT; BRENT R. STOCKWELL; VALERIAN E. KAGAN; BRIAN HEAD
Revista:
GENES & DEVELOPMENT.
Editorial:
COLD SPRING HARBOR LAB PRESS
Referencias:
Año: 2018 vol. 32 p. 602 - 619
ISSN:
0890-9369
Resumen:
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
