Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic

CHISARI, A; SANCHO, P.; CAJA, L.; BERTRAN, E.; FABREGAT, I.

CELLULAR SIGNALLING

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2012 vol. 24 p. 325 - 332

0898-6568

Protein malnutrition occurs when there is insufficient protein to meet metabolic demands. Previous works have indicated that cycles of protein fasting/refeeding enhance the incidence of early lesions during chemical carcinogenesis in rat liver. The general objective of this work was to study the effect of aminoacids (Aa) deprivation on the proliferation and survival of hepatocytes, to understand its possible involvement in the generation of pre-neoplastic stages in the liver. Lackficient protein to meet metabolic demands. Previous works have indicated that cycles of protein fasting/refeeding enhance the incidence of early lesions during chemical carcinogenesis in rat liver. The general objective of this work was to study the effect of aminoacids (Aa) deprivation on the proliferation and survival of hepatocytes, to understand its possible involvement in the generation of pre-neoplastic stages in the liver. Lack