INV SUPERIOR JUBILADO
PERDIGON Gabriela Del Valle
capítulos de libros
Título:
Antitumour activity of yoghurt
Autor/es:
DE MORENO DE LEBLANC, ALEJANDRA; PERDIGON, GABRIELA
Libro:
Focus on Colorectal Cancer Research
Editorial:
Nova Science Publisher Inc
Referencias:
Lugar: Hauppauge, NY, USA; Año: 2005; p. 115 - 140
Resumen:
Several studies have demonstrated that fermented milk consumption decrease the
incidence of colorectal cancer. Using a chemically induced murine colon cancer model it
was reported that conventional yoghurt inhibits tumour development. In this model, the
inflammatory immune response caused by the carcinogen (DMH) showed a great
increase in IgG+ B cells, CD8+ T lymphocytes and in proinflammatory cytokines (TNFa
and IFNg). Yoghurt feeding inhibited tumour development by decreasing the
inflammatory immune response and increasing the number of IgA+ cells, CD4+ T
lymphocytes, cytokines such as Il-10 and decreasing NO radicals. Yoghurt also induced
the apoptosis mechanisms. The local immune stimulation produced by yoghurt feeding
increased monocytes/macrophages population and the cytokines release in the nodular
tissue and in the Peyers patches suggesting that these cells could be responsible for IFNãã
and TNFá production. The enhancement of IL-10 found would favour the regulation of
the immune response, not only in the inhibition model of the tumour growth, but also
when yoghurt is given long term. The immune mechanisms involved by yoghurt to
decrease the inflammatory immune response caused by the carcinogen were different to
those observed with an antiinflammatory drug (indomethacin). Indomethacin did not
increase immune infiltrative cell activity in the large intestine and the cytokine levels
were diminished. Nitric oxide synthase enzyme determinations showed that in mice fed
with yoghurt, the IFNã enhancement was not related to inflammation, but to an
immunomodulation. We demonstrated that the only single yoghurt supplementation was
unable to inhibit tumour development in the initiation stage, however it inhibited the
tumour growth (promption and progression) when it was administered cyclically after
tumour induction. Cellular apoptosis increase observed could explain the importance for
the TNFá levels found in the mice fed long term with yoghurt. The normal microflora
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.
tumour growth (promption and progression) when it was administered cyclically after
tumour induction. Cellular apoptosis increase observed could explain the importance for
the TNFá levels found in the mice fed long term with yoghurt. The normal microflora
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.á production. The enhancement of IL-10 found would favour the regulation of
the immune response, not only in the inhibition model of the tumour growth, but also
when yoghurt is given long term. The immune mechanisms involved by yoghurt to
decrease the inflammatory immune response caused by the carcinogen were different to
those observed with an antiinflammatory drug (indomethacin). Indomethacin did not
increase immune infiltrative cell activity in the large intestine and the cytokine levels
were diminished. Nitric oxide synthase enzyme determinations showed that in mice fed
with yoghurt, the IFNã enhancement was not related to inflammation, but to an
immunomodulation. We demonstrated that the only single yoghurt supplementation was
unable to inhibit tumour development in the initiation stage, however it inhibited the
tumour growth (promption and progression) when it was administered cyclically after
tumour induction. Cellular apoptosis increase observed could explain the importance for
the TNFá levels found in the mice fed long term with yoghurt. The normal microflora
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.
tumour growth (promption and progression) when it was administered cyclically after
tumour induction. Cellular apoptosis increase observed could explain the importance for
the TNFá levels found in the mice fed long term with yoghurt. The normal microflora
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.ã enhancement was not related to inflammation, but to an
immunomodulation. We demonstrated that the only single yoghurt supplementation was
unable to inhibit tumour development in the initiation stage, however it inhibited the
tumour growth (promption and progression) when it was administered cyclically after
tumour induction. Cellular apoptosis increase observed could explain the importance for
the TNFá levels found in the mice fed long term with yoghurt. The normal microflora
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.
tumour growth (promption and progression) when it was administered cyclically after
tumour induction. Cellular apoptosis increase observed could explain the importance for
the TNFá levels found in the mice fed long term with yoghurt. The normal microflora
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.
has an important function in the intestinal inflammatory process preceding tumour
development, lactic acid bacteria present in yoghurt play a role in this process since it has
been shown that these bacteria and fermented milk products act on the microbial enzyme
activities associated with colon carcinogenesis. This chapter will show that yoghurt can
inhibit the promotion and progression of chemically induced colon cancer in mice
through its antiinflammatory effect, cell apoptosis and by its immunomodulating
properties.