High-fat diet and (‒)-epicatechin supplementation: comparative effects on cardiac and skeletal-muscle.

FISCHERMAN L; RUKAVINA MIKUSIC IA; PIOTRKOWSKI B; GALLEANO M; FRAGA CG; VALDEZ LB

Ferrara

Congreso; SFRR-E 2019 Annual Meeting. Redox homeostasis: from signaling to damage?; 2019

Society for Free Radical Research-Europe

In this work, we studied (‒)-epicatechin (EC) effects on cardiac (CM) and skeletal muscle (SM) mitochondrial function from high-fat fed mice. Male mice were fed for 15 w with diets containing 10% total calories from fat (C), 60% total calories from fat (HF), C diet added with EC to provide 20 mg EC/kg body (CE), and HF diet plus same amount of EC (HFE). Mitochondrial respiratory complexes I-III, II-III, and IV activities were higher in CM (27%, 24% and 27%) and SM (28%, 43% and 43% respectively; p