The mitochondrial nitric oxide synthase

BOVERIS A; NAVARRO A; LORES ARNAIZ S; VALDEZ LB; ALVAREZ S

Proceedings of the XI Biennial Meeting of the Society for Free Radical Research International

Monduzzi Editore SpA - Medimond Inc.

Lugar: Bologna, Italy; Año: 2002; p. 97 - 102

Mitochondrial nitric oxide synthase (mtNOS) is a protein constitutive of the inner mitochondrial membrane recognized in liver, brain, heart, thymus, and kidney. Its enzymatic activity generates an intramitochondrial steady state [NO] of about 40 nM that exerts a regulatory functional activity in modulating (a) cytochrome oxidase activity and respiration, and (b) mitochondrial H2O2 production.