Nitric oxide and superoxide radical production by human lymphocytes

VALDEZ LB; BOVERIS A

Proceedings of the XI Biennial Meeting of the Society for Free Radical Research International

Monduzzi Editore SpA - Medimond Inc.

Lugar: Bologna, Italy; Año: 2002; p. 71 - 74

Non-stimulated human lymphocytes take up O2 and produce and release NO, O2-, and H2O2 at rates that are increased 2-3 fold by PMA addition. Stimulated lymphocytes triggered luminol chemiluminescence that was 91% inhibited by L-NMMA and SOD, identifying the generation of ONOO-. Basal and stimulated production of NO, and H2O2 by human lymphocytes may have a role in intercellular signaling.