mtNOS: regulation by mitochondrial membrane potential

ZAOBORNYJ T; VALDEZ LB

Free Radicals and Diseases: Gene expression, cellular metabolism and pathophysiology

IOS Press - NATO Science series

Lugar: Amsterdam, Netherlands; Año: 2005; p. 35 - 42

The state 4-state 3 transition regulates NO release in coupled mitochondria, the rates were 40-50 % lower in state 3 than in state 4. The rates of NO production by liver and kidney mitochondria were 1.3 and 0.7 nmol/min.mg protein in state 4, and 0.7 and 0.4 nmol/min.mg protein in state 3. The state 4-state 3 transition regulates NO production by the transition of mitochondrial membrane potential and not of intramitochondrial pH. Nitric oxide production was voltage dependent showing higher rates at higher mitochondrial membrane potentials