The pro-apoptotic galectin-1 is functionally inhibited in inflamed areas of IBD patients

PAPA GOBBI RODRIGO; SAMBUELLI ALICIA; ROCCA ANDRES; MUGLIA CECILIA; IRIGOYEN ANDRÉS; BELLICOSO MARICEL; GIL ANÍBAL; GONCALVES SILVINA; HUERNOS SERGIO; NEGREIRA SILVIA; TIRADO PABLO; YANTORNO MARTÍN; TOSCANO MARTA; MUGLIA CECILIA; RABINOVICH GABRIEL; DOCENA GUILLERMO H.

Conpenhagen

Congreso; ECCO - European Crohn´s and Colitis Organisation Congress 2013; 2013

ECCO

Inflammatory bowel diseases (IBD) are multifactorial disorders characterized by a chronic and relapsing intestinal inflammation. Galectin-1, a ubiquitous endogenous lectin, has been implicated in several chronic inflammatory disorders. We aimed to analyze its role in the colonic mucosa of patients with Crohn´s disease (CD) and Ulcerative colitis (UC). Gal-1 expression was studied by qPCR, immunoblotting and histology in biopsies and resected tissues of patients with IBD (n=26) and control patients (n=20). Gal-1-specific binding ligands were also analyzed by flow cytometry in lamina propria and its physiologycal role in the induction of cell death was evaluated by flow cytometry. We found in 21 biopsies of CD and 22 biopsies of CU that Gal-1 mRNA expression was increased in colonic inflamed areas (p