INVESTIGADORES
DOCENA Guillermo Horacio
artículos
Título:
The role of transforming growth factor (TGF)-â in modulating the immune response and fibrogenesis in the gut.
Autor/es:
BIANCHERI PAOLO; GIUFFRIDA PAOLO; DOCENA GUILLERMO; MACDONALD THOMAS; GINO R. CORAZZA; ANTONIO DI SABATINO
Revista:
CYTOKINE & GROWTH FACTOR REVIEWS
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2013 p. 1 - 11
ISSN:
1359-6101
Resumen:
Transforming growth factor (TGF)-b, an immunoregulatory cytokine released by gut epithelial cells, fibroblasts, regulatory T cells (Treg) and macrophages, plays a key role in mucosal immune homeostasis. TGF-b exerts its mucosal tolerogenic action by inhibiting pro-inflammatory T helper 1 cell differentiation and by promoting Treg development. TGF-b signaling plays a central role in dampening gut inflammation and its impairment in inflamed Crohn?s disease mucosa is an important factor contributing to the chronic inflammatory process. TGF-b, which is increased in the intestinal strictures of Crohn?s disease patients, exerts also a potent pro-fibrogenic action in the gut, where it promotes abnormal extracellular matrix synthesis. Hence, strategies aimed at restoring TGF-b signaling to normal levels in inflammatory bowel disease will be discussed.
