Sputnik V Vaccine Elicits High Neutralizing Capacity to SARS-CoV-2 After a Single Dose in Previously Infected Individuals

ROSSI, ANDRES; OJEDA, DIEGO; VARESE, AUGUSTO; SANCHEZ, LAUTARO; GONZALEZ LOPEZ LEDESMA, MARIA; MAZZITELLI, IGNACIO; ALVAREZ JULIA, ANABEL; OVIEDO ROUCO, SANTIAGO; DOCENA GUILLERMO; GEFFNER, JORGE; PIFANO MARINA; GAMARNIK, ANDREA

Cell Reports Medicine

Cell Press

Año: 2021

2666-3791

Massive vaccination offers great promise for halting the global COVID-19 pandemic. However,limited supply and uneven vaccine distribution create an urgent need to optimize vaccinationstrategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination ofhealthcare workers in Argentina, measuring IgG anti-spike titers and neutralizing capacity afterone and two doses in a cohort of naïve or previously infected volunteers. By 21 days afterreceiving the first dose of vaccine, 94% of naïve participants develop spike-specific IgGantibodies. A single Sputnik V dose elicits higher antibody levels and virus neutralizing capacityin previously infected individuals than in naïve ones receiving the full two-dose schedule. Thehigh seroconversion rate after a single dose in naïve participants suggests a benefit of delayingsecond dose administration to increase the number of people vaccinated. The data presentedprovide information for guiding public health decisions in light of the current global healthemergency.