INVESTIGADORES
DAVIO Carlos Alberto
artículos
Título:
Semen promotes the differentiation of tolerogenic dendritic cells.
Autor/es:
REMES LENICOV, F; RODRIGUEZ RODRIGUES, C.; SABATTÉ, J; CABRINI, M.; JANCIC, C.; OSTROWSKI, M.; MERLOTI, A.; GONZALEZ, H.; DONALDSON, M; PASQUALINI, R.S; DAVIO CARLOS; GEFFNER, J; CEBALLOS, A
Revista:
JOURNAL OF IMMUNOLOGY
Editorial:
AMER ASSOC IMMUNOLOGISTS
Referencias:
Lugar: Bethesda; Año: 2012 vol. 189 p. 4777 - 4786
ISSN:
0022-1767
Resumen:
Seminal plasma is not just a carrier for spermatozoa. It contains high concentrations of cytokines, chemokines, and other biological
compounds that are able to exert potent effects on the immune system of the receptive partner. Previous studies have shown that
semen induces an acute inflammatory response at the female genital mucosa after coitus. Moreover, it induces regulatory mechanisms
that allow the fetus (a semiallograft) to grow and develop in the uterus. The mechanisms underlying these regulatory mechanisms,
however, are poorly understood. In this study, we show that seminal plasma redirects the differentiation of human dendritic
cells (DCs) toward a regulatory profile. DCs differentiated from human monocytes in the presence of high dilutions of seminal
plasma did not express CD1a but showed high levels of CD14. They were unable to develop a fully mature phenotype in response
to LPS, TNF-a, CD40L, Pam2CSK4 (TLR2/6 agonist), or Pam3CSK4 (TLR1/2 agonist). Upon activation, they produced low
amounts of the inflammatory cytokines IL-12p70, IL-1b, TNF-a, and IL-6, but expressed a high ability to produce IL-10 and
TGF-b. Inhibition of the PG receptors E-prostanoid receptors 2 and 4 prevented the tolerogenic effect induced by seminal plasma
on the phenotype and function of DCs, suggesting that E-series PGs play a major role. By promoting a tolerogenic profile in DCs,
seminal plasma might favor fertility, but might also compromise the capacity of the receptive partner to mount an effective
immune response against sexually transmitted pathogens.