Zinc deficiency and high fat diet during growth predispose to metabolic disorders in adult life

GIACOMAZZI, JULIA; MAGALDI, ROCÍO; SORIA, DAMIÁN ARIEL; ZAGO, VALERIA; ELESGARAY, ROSANA; PÁEZ, DIAMELA; PIOVAROLI, FLORENCIA; MARTÍNEZ TAMBELLA, JOAQUÍN; SARAVIA FILECCIA, MELISA; MENDES GARRIDO, FACUNDO; ARRANZ, CRISTINA; TOMAT, ANALÍA; CIANCIO DEL GIUDICE, NICOLÁS ESTEBAN; SOSA, AGUSTINA; RAMÍREZ, HERNÁN; SCHREIER, LAURA; CANIFFI, CAROLINA

Congreso; SCHCF + ALACF 2020 Joint Meeting; 2020

Asociación Latino Americana de Ciencias Fisiológicas

Introduction: Zinc deficiency can coexist with overweight and obesity during growth predisposing to metabolic disorders in adultlife. Objective: We evaluated if fetal and postnatal zinc deficiency exacerbates the extent of adiposity and metabolic dysfunctioninduced by high fat diet (HFD) in male adult rats. Methodology: Female Wistar rats received low (L:8ppm) or control (C:30ppm)zinc diets from pregnancy to offspring weaning. C male offspring continued with C(C) or HFD (60% of total calories)(CH) diets. Loffspring were fed L(L) or L and HFD(LH) diets. At day 81, blood oxidative stress, glucose tolerance test (GTT), lipid profile, andmorphology, adiponectin expression and oxidative state of retroperitoneal adipose tissue (RPAT) were measured. Two wayANOVA, Bonferroni post-test, mean±SEM,*p