IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Beneficial cardiac effects of enalapril in postmenopausal hypertensive rats
Autor/es:
ZILBERMAN JUDITH; YANES LICY; TOMAT ANALIA; ROMERO MARIANA; SARTORI-VALLINOTI JULIO; ELESGARAY ROSANA; COSTA MARIA DE LOS ANGELES; RECKELHOFF JANE; ARRANZ CRISTINA
Lugar:
New Orleans, USA
Reunión:
Congreso; Experimental Biology 2009; 2009
Institución organizadora:
American Physiology Society
Resumen:
Several studies suggest an interaction between renin-angiotensin system and estrogen with nitric oxide (NO) system
and oxidative stress. Objective: To evaluate the effects of the angiotensin-converting enzyme inhibitor enalapril (E)
on systolic blood pressure (SBP), oxidative stress, NO synthase (NOS) activity and estrogen receptors expression in
the left ventricle (LV) of postmenopausal spontaneously hypertensive rats (OF-SHR). aged 16 month received E 250
mg/L in drinking water or tap water (C) for 30 days. At the end of the treatment lipid peroxidation end products
(TBARS), estrogen receptors expression, catalase (CAT), glutathion peroxidase (GPx) and NOS activity were
measured in LV. Results: Treatment with enalapril decreased SBP and lipid peroxidation but increased GPx and NOS
activity in OF- SHR. Estrogen receptor ¦Â was upregulated by E treatment in LV of OF-SHR.
SBP TBARS CAT GPx NOS activity
(mmHg) (ng/mg.prot) (pmol/mg.prot) ( pmol/min.mg.prot) (pmol.citrulline14C/g tissue. min)
C 174¡À10 0.215¡À0.029 0.062¡À0.006 2.30¡À0.10 348.1¡À3.8
E 152¡À9# 0.137¡À0.006* 0.039¡À0.009 2.94¡À0.20* 445.3¡À13.5*
* p<0.02 vs control, #p<0.01 vs control.
In conclusi¨®n, our study shows that enalapril administration caused a reduction in oxidative stress and increases in
NOS activity and estrogen receptor ¦Â expression in LV of OF-SHR. These results suggest that changes observed in
the LV after menopause may be Angiotensin II mediated.