ALTERATIONS IN INTERMEDIATE METABOLISM AND AORTA MORPHOLOGY INDUCED BY ZINC DEFICIENCY AND/OR HIGH FAT DIET DURING GROWTH.

AGUSTINA MEDINA; MORIONDO MARISA MABEL; FACUNDO MENDES GARRIDO ABREGÚ; CRISTINA ARRANZ; JULIA, GIACOMAZZI; VALERIA ZAGO; CAROLINA CANIFFI; ANALÍA TOMAT; DIAMELA TATIANA PAEZ; LAURA SCHREIER; ROSANA ELESGARAY

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Lugar: Buenos Aires; Año: 2021

0025-7680

Introduction: Zinc deficiency can coexist with overweight and obesity during growth predisposing to metabolic disorders in adult life.Objective: To evaluate, in adult male rats, alterations in intermediate metabolism and aorta morphology induced by fetal and postnatal zinc deficiency and/or high fat diet during post weaning life.Methodology: Female Wistar rats received low (L:8ppm) or control (C:30ppm) zinc diets from pregnancy to offspring weaning. C male offspring continued with C(C) or HFD (60% of total calories) (CH) diets. L offspring were fed L(L) or L and HFD(LH) diets. At day 81, we determined blood oxidative stress, glucose tolerance test (GTT), lipid profile, plasmatic adiponectin levels and thoracic aorta morphology. Two way ANOVA, Bonferroni post-test, mean±SEM,*p