IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
EFFECT OF CARDIAC RENIN ANGIOTENSIN SYSTEM AXIS ON MALE AND FEMALE RATS EXPOSED TO MODERATE ZINC RESTRICCION DURING FETAL AND POSTNATAL LIFE.
Autor/es:
PAEZ, DIAMELA TATIANA; JULIA GIACOMAZZI; CAROLINA CANIFFI; ANALÍA TOMAT; FACUNDO MENDES GARRIDO ABREGÚ; MARIELA GIRONACCI; CRISTINA ARRANZ; MARÍA NATALIA GOBETTO; AGUSTINA MEDINA; ROSANA ELESGARAY
Revista:
MEDICINA (BUENOS AIRES)
Editorial:
MEDICINA (BUENOS AIRES)
Referencias:
Lugar: Buenos Aires; Año: 2021
ISSN:
0025-7680
Resumen:
Introduction: We have demonstrated that zinc deficiency during pregnancy and postnatal life induced cardiovascular alterations in males. Females did not show significant heart alterations.Objective: Evaluate cardiac renin angiotensin system in adult rats exposed to zinc deficiency during growth.Methods: Female Wistar rats fed either control (C30ppm) or low zinc (L8ppm) diets from pregnancy to offspring weaning. C male and female offspring continued with control diet (Ccm;Ccf respectively), whereas L male and female offspring fed control (Lcm;Lcf) or low zinc (Llm;Llh) diets. At day 81 we measured in left ventricle: Angiotensin (Ang) II, Ang(1-7) levels by radioimmunoassay, Angiotensin converting enzyme 1(ECA1),ECA2 and AT1 receptor (AT1R) expression by RT-qPCR; AT2R and AT1R expression by western blot and immunohistochemistry. Values are means±SEM, Two-way ANOVA, Bonferroni post-test. *p
