IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
Autor/es:
MOUSAVI, SEYED T.; ASHTON, MARK D.; OIKONOMOU, VASILEIOS K.; MURDOCK, BETHANY E.; BALDOCK, SARA J.; ROBINSON, BENJAMIN J.; HARPER, GARRY R.; TOWNSEND, DAVID; FIRLAK, MELIKE; AKIEN, GEOFFREY R.; FAZILATI, MOHAMAD; DESIMONE, MARTIN F.; MUNICOY, SOFIA; ALSHARIF, GHAZI H. K.; AU-YONG, SOPHIE; HALCOVITCH, NATHAN R.; KOLOSOV, OLEG V.; HARDY, JOHN G.
Revista:
MACROMOLECULAR MATERIALS AND ENGINEERING (PRINT)
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Año: 2020 vol. 2000 p. 1 - 7
ISSN:
1438-7492
Resumen:
Biomaterials capable of controlling the delivery of drugs have the potentialto treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film-based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β-sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3-amino-4-hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by avariety of techniques including circular dichroism, Fourier-transform infraredspectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistancemeasurements, scanning electron microscopy-energy dispersive X-ray spectroscopy,thermogravimetric analysis, X-ray diffraction, and X-ray photoelectronspectroscopy). Fibroblasts adhere on the surface of the biomaterials (viabilityassessed using an (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)assay and visualized using a confocal microscope), and a fluorescently labeleddrug (Texas-Red Gentamicin) can be loaded electrochemically and released(μg cm−2 quantities) in response to the application of an electrical stimulus