Microspheres/Custard Apples Copper (II) Chelate Polymer: Characterization, Docking, Antioxidant and Antibacterial Assay

BAGADE, REENA; MONDAL, ANIRUDDHA; MISHRA, RAGHVENDRA; POTBHARE, AJAY; DADURE, KANHAIYA; CHAUDHARY, RATIRAM GOMAJI; DESIMONE, MARTIN; JUNEJA, HARJEET

ChemistrySelect

Willey

Año: 2019 vol. 4 p. 6233 - 6244

2365-6549

In the present study we have reported fabrication and structural determination of 3D microspheres/custard-apples shaped mesoporous CuII chelate polymer (CP) from a 1Dchelating ligand for enhanced an antioxidant and antibacterial activities. The CP was fabricated from a novel chelating ligand suberoyl bis(2-ethoxybenzamide) (sbebz) with copper salt by condensation, while sbebz was synthesized from 2-ethoxybenzamideand suberoyl chloride, and was structurally authenticated by 1HNMR, 13CNMR, FT-IR, Mass spectroscopy, XRD, and SEM. As-fabricated CP was characterized by XRD, FT-IR, EDS, UV-DRS, XPS, Raman, SEM, TEM, AFM, BET, and TG for authentication of its structure, shape, size, chemical state, composition, purity, surface behavior, porosity, and thermal stability. SEM revealed nearly monodispersity in microspheres, while TEM rendered average particles sizes of 10?47 nm. AFM supported nearly homogenized nature of microspheres, while BET rendered a mesoporosity. Further, antioxidant property ofCP was examined by using α, α-diphenyl-β-picrylhydrazyl (DPPH) in ethanolic/methanolic solvents, while ascorbic acid was used as a standard medium. Furthermore, the antibacterialactivity of both materials was tested against human pathogenic bacteria viz. gram +Ve (Staphylococcus aureus, and Bacillus substilis), and gram ?Ve (Escherichia coli and Klebsiella pneumoniae). Moreover, molecular docking of sbebz was performedusing both genetic (GA) and non-genetic (Non-GA) algorithm techniques, where result demonstrated an excellent docking energy.