IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Development and evaluation of thymol-chitosan hydrogels with antimicrobial-antioxidant activity for oral local delivery
Autor/es:
ECHAZÚ, MARÍA INÉS ALVAREZ; PEREZ, CLAUDIO JAVIER; OLIVETTI, CHRISTIAN EZEQUIEL; ALVAREZ, GISELA SOLANGE; ANESINI, CLAUDIA; DESIMONE, MARTIN FEDERICO
Revista:
MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2017 vol. 81 p. 588 - 596
ISSN:
0928-4931
Resumen:
Nowadays, the research of innovative drug delivery devices is focused on the design of multiple drug deliverysystems, the prevention of drug side effects and the reduction of dosing intervals. Particularly, new mucosaldelivery systems for antimicrobials, antioxidants and anti-inflammatory drugs has a growing development, regardsto the avoidance of side effects, easy administration and a suitable drug concentration in the mucosa. Inthis work, chitosan hydrogels are evaluated as a biodegradable scaffold and as a bioactive agent carrier of anantioxidant-antimicrobial compound called thymol.Throughout the study, swelling behavior, viscoelastic properties and thermal analysis are highlighted topresent its advantages for a biomedical application. Furthermore, the in vitro results obtained indicate thatthymol-chitosan hydrogels are biocompatible when exposed to [3T3] fibroblasts, exhibit antimicrobial activityagainst Staphylococcus aureus and Streptococcus mutans for 72 h and antioxidant activity for 24 h. These aredesirable properties for a mucosal delivery system for an antimicrobial-antioxidant dual therapy for periodontaldisease.