IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Natural Sesquiterpene Lactones as Potential Trypanocidal Therapeutical Agents: A Review
Autor/es:
JERONIMO ULLOA ; LILIANA MUSCHIETTI
Revista:
NATURAL PRODUCT COMMUNICATIONS
Editorial:
NATURAL PRODUCTS INC
Referencias:
Lugar: Westerville; Año: 2016 vol. 11 p. 1569 - 1578
ISSN:
1934-578X
Resumen:
Natural Product Communications2016Volume 11, Number 10, Pages 1569-1578Natural Sesquiterpene Lactones as Potential TrypanocidalTherapeutic Agents: A ReviewLiliana V. Muschietti and Jerónimo L. UlloaAbstract - Chagas? disease and Human African Trypanosomiasis are parasitic diseasesthat remain major health problems, mainly among the poorest and the most marginalizedcommunities from Latin America and Africa. The scarcity of effective chemotherapy,due to the low investment in the research and development (R&D) of new drugs, togetherwith a high incidence of side effects, and the emergence of drug resistance phenomenaemphasize the urgent need for new prophylactic and therapeutic agents. Over the ages,humans have employed natural products to treat a wide spectrum of diseases. Recently,the pharmaceutical industry has focused on plant research and a large body of evidencehas been collected to demonstrate the immense potential of medicinal plants as a sourceof bioactive compounds and lead molecules. In the field of parasitic diseases, drugdevelopment from plants has been successful for the sesquiterpene lactone (STL)artemisinin, which is employed as an antimalarial agent. STLs are a large group ofnaturally occurring terpenoids derived from plants that mostly belong to the Asteraceaefamily which exhibit a variety of skeletal arrangements and are the largest and mostdiverse category of natural products with an α- methylene-λ-lactone motif. STLs displaya broad spectrum of biological activities such as antitumor, cytotoxic, antibacterial,anthelmintic, uterus contracting, antimalarial, neurotoxic, antiprotozoal and allergic(contact dermatitis) activities. In this context, the purpose of the present review is toprovide an overview of the trypanocidal activity reported for STLs against Trypanosomacruzi and T. brucei rhodesiense over the period 1993-2015.