IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Advances in collagen, chitosan and silica biomaterials in oral tissue regeneration: from basics to clinical trials
Autor/es:
M. V. TUTTOLOMONDO; G. S. ALVAREZ; M. I. ALVAREZ ECHAZU; A. M. MEBERT; M. L. FOGLIA; M. F. DESIMONE
Revista:
Journal of Materials Chemistry B
Editorial:
Royal Society of Chemistry
Referencias:
Lugar: CAMBRIDGE; Año: 2016 vol. 4 p. 6913 - 6929
ISSN:
2050-750X
Resumen:
Different materials have distinct surface and bulk characteristics; each of them is potentially useful for the treatment of a particular wound or disease. By reviewing those materials that have reached a clinical stage the reader will have a broad panorama of the possibilities a particular material can offer, regarding its ability to support fast tissue regeneration. This review covers the most recent advances made towards the development of biomaterials aimed to support regenerative process. Indeed, we highlight key examples, from basic research to clinical trials, of biomaterials for a specific biomedical application. In this context, the focus is made on collagen, chitosan and silica which are key representatives of a protein, a polysaccharide and an inorganic material usually employed as biomaterials. Particularly, this review article presents an overview of their potential therapeutics in the treatment of disorders within the oral mucosa and tooth supporting tissues. Finally, it is highlighted the importance of in vivo and in vitro studies, clinical evidence studies, systematic reviews and meta-analyses as an adequate guidance for biomaterial design and development.