IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Moderate zinc restriction during fetal and postnatal growth of rats: effects on adult arterial blood pressure and kidney
Autor/es:
TOMAT A.; INSERRA F.; VEIRAS L; VALLONE C.; BALASZCZUK A.; COSTA A.; ARRANZ C
Revista:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Editorial:
American Society of Physiology
Referencias:
Lugar: USA; Año: 2008 vol. 295 p. 543 - 549
ISSN:
0363-6119
Resumen:
Intrauterine and postnatal zinc restriction may result in an adverse environment for the
development of cardiovascular and renal systems. This study evaluated the effects of moderate
zinc deficiency during fetal life, lactation and/or post-weaning growth on systolic blood pressure,
renal function and morphology in adult life.
Female Wistar rats received low (8 ppm) or control (30 ppm) zinc diets from the beginning of
pregnancy up to weaning. After weaning, male offspring of each group of mothers were fed low
or control zinc diet. Systolic blood pressure, creatinine clearance, proteinuria, renal morphology,
renal apoptosis and renal oxidative stress state were evaluated after 60 days.
Zinc deficiency during pre- and post-weaning growth induced an increase in systolic blood
pressure and a decrease in the glomerular filtration rate associated with a reduction in the number
and size of nephrons. Activation of renal apoptosis, reduction in catalase activity, glutathione
peroxidase activity and glutathione levels and increase in lipid peroxidation end-products could
explain these morphometric changes. Zinc deficiency through pre- and post-weaning growth
induced more pronounced renal alteration than post-weaning zinc deficiency. These animals
showed signs of renal fibrosis, proteinuria, increased renal apoptosis and higher lipid
peroxidation end-products. A control diet during post-weaning growth did not totally overcome
renal oxidative stress damage, apoptosis and fibrosis induced by zinc deficiency before weaning.
In conclusion, zinc deficiency during a critical period of renal development and maturation could
induce functional and morphological alterations that result in elevated blood pressure and renal
dysfunction in adult life.
Key words: renal function and morphology, renal apoptosis, renal oxidative stress, early renal
fibrosis
fibrosis
fibrosis
fibrosis
fibrosis
: renal function and morphology, renal apoptosis, renal oxidative stress, early renal
fibrosis