Larrea divaricata Cav (Jarilla): production of superoxide anion, hydrogen peroxide and expression of zymosan receptors.

ROBERTO DAVICINO; CAROLINA MARTINEZ; M. AÍDA MATTAR; YOLANDA CASALI; SILVIA G. CORREA; LESLIE ARAGON; ELBIO ANTONIO SAIDMAN; GERMÁN MESSINA; BLAS MICALIZZI

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Taylor & Francis Group

Lugar: Londres; Año: 2008 vol. 30 p. 481 - 501

0892-3973

Larrea divaricata is a plant widely used in folk medicine in Argentine. This work aimed to study the mechanisms of decoction activity on the release of oxygen reactive species. Decoction increased the binding of zymosan-FITC and superoxide production. Cadmiun decreased the superoxide production as well as malonate and barbital. Decoction decreased the release of hydrogen peroxide. Decoction increased the reduction of MTT but not when malonate and barbital were included. Together, decoction increased the expression of dectin-1 leading to increased superoxide production. It is possible that decoction increases the activity of peroxidase, and decreases the Cu, Zn-superoxide dismutase.