Controlling the Interaction Between Cells and Silica Nanoparticles

MEBERT, ANDREA MATHILDE; CAMPOROTONDI, DANIELA EDHIT; FOGLIA, MARÍA LUCIA; ALVAREZ, GISELA SOLANGE; SANTO ORIHUELA, PABLO LUIS; DIAZ, LUIS EDUARDO; DESIMONE, MARTÍN FEDERICO

Journal of Biomaterials and Tissue Engineering

American Scientific Publishers

Lugar: California; Año: 2013 vol. 3 p. 108 - 121

2157-9083

In recent years, the application of silica nanoparticles in the biomedical fieldexperienced a great development, showing a sharp increase in the number of publishedarticles and patents. The driving forces for these and future developments are thepossibility to design nanoparticles with homogeneous size and structure and amenableto specific grafting. In this way, it is possible to control the interaction of nanoparticleswith cells. Moreover, it is possible to tune the characteristics of the nanoparticles tomeet the requirements of each specific cell and desired application. Herein, we presentdifferent strategies developed to optimize the size, morphology, surface topography,elemental ratio, hydrophobic/hydrophilic balance, and erosion rate, which contribute tounderstand the nature of this inherently complicated cell-nanoparticles interactionsmechanism, which will determine the resulting function performance.