CONICET | Buscador de Institutos y Recursos Humanos

The aim of this study was to evaluate whether moderate zinc restriction in rats throughout fetal life, lactation and/or post-weaning growth results in early changes in cardiac morphology predisposing the onset of cardiac dysfunction in adult life, and sex39 related differences in the adaptation to this nutritional injury. Female Wistar rats received low or control zinc diets from the beginning of pregnancy up to weaning. After weaning, offspring were fed either a low or control zinc diet until 81 days. Systolic blood pressure was measured. Echocardiographic and electrocardiographic examinations, morphological studies and apoptosis by TUNEL assay were performed in left ventricle. In early stages, zinc-deficient male and female offspring showed an increase in cardiomyocyte diameter, probably associated with an increase in cardiac apoptotic cells, but smaller myocyte diameters in adulthood. In adult males, this nutritional injury induced decreased contractility and dilatation of the left ventricle, not allowing the heart to compensate the higher levels of blood pressure, and hypertrophic remodeling of coronary arteries associated with increased blood pressure. Adequate zincintake during post-weaning life did not overcome blood pressure levels but reversedsome of the detrimental effects of earlier zinc deficiency in cardiac morphology andfunction. Females were less sensitive to this deficiency, exhibiting normal levels of blood pressure and no structural or functional heart alterations in adult life. The present study demonstrate that the effects of zinc deficiency on blood pressure, cardiac morphology and function differ between sexes, with males more predisposed to develop cardiovascular diseases in adulthood.