Peroxidase secretion in rat submandibular glands induced by PGE2: Role of cAMP and nitric oxide

CLAUDIA ANESINI,; GRACIELA FERRARO,

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

ELSEVIER

Año: 2006 vol. 74 p. 303 - 308

0952-3278

Free radicals are associated to the appearance of disorders such as tumours, CNS alterations and inflammatory pathologies. Their levels are known to be increased in inflammatory diseases due  to the activity of prostaglandins, which are related to protein secretion including enzymes. Peroxidase is an oral enzyme which is implicated in the defence of the oral cavity. In this paper  investigations of the effect and mechanism of the activity of prostaglandin E2 (PGE2) on peroxidase secretion of female rat submandibular glands is reported. Results showed that, PGE2 significantly increased the secretion of submandibular peroxidase, and that this effect was mediated by an increase of intracellular cAMP and nitric oxide synthase activation. This could imply that protaglandins play a modulatory role in diseases where free radicals are involved.