IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
In vitro evaluation of antiprotozoal and antiviral activities of extracts from Argentinean Mikania species
Autor/es:
LAURELLA L; FRANK F; SARQUIZ A; ALONSO MR; GIBERTI G; CAVALLARO L; CATALAN C; CAZORLA S; MALCHIODI E; MARTINO V; SÜLSEN V
Revista:
SCIENTIFIC WORLD JOURNAL, THE
Editorial:
THESCIENTIFICWORLD LTD
Referencias:
Lugar: New York; Año: 2012 p. 1 - 6
ISSN:
1537-744X
Resumen:
The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6 ± 4.5% and 84.9 ± 6.1%, respectively, at a concentration of 10ìg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2.
