IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Prevention of Hidrogen Peroxide-Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds.
Autor/es:
PERALTA; COGOI, L.,; FILIP, R.; ANESINI, C
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
John Wiley & Sons, Ltd.
Referencias:
Año: 2012
ISSN:
1099-1573
Resumen:
The fresh leaves and stems of Ilex paraguariensis (Aquifoliaceae) are employed to prepare the commercial product
used in North-eastern Argentina, Southern Brazil and Eastern Paraguay named yerba maté. The presence of
polyphenols and xanthines, which present antioxidant activity, has been described in I. paraguariensis. In living
organism, reactive oxygen species can cause tissue damage affecting erythrocyte membranes leading to hemolysis.
The aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
organism, reactive oxygen species can cause tissue damage affecting erythrocyte membranes leading to hemolysis.
The aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
used in North-eastern Argentina, Southern Brazil and Eastern Paraguay named yerba maté. The presence of
polyphenols and xanthines, which present antioxidant activity, has been described in I. paraguariensis. In living
organism, reactive oxygen species can cause tissue damage affecting erythrocyte membranes leading to hemolysis.
The aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
organism, reactive oxygen species can cause tissue damage affecting erythrocyte membranes leading to hemolysis.
The aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
Ilex paraguariensis (Aquifoliaceae) are employed to prepare the commercial product
used in North-eastern Argentina, Southern Brazil and Eastern Paraguay named yerba maté. The presence of
polyphenols and xanthines, which present antioxidant activity, has been described in I. paraguariensis. In living
organism, reactive oxygen species can cause tissue damage affecting erythrocyte membranes leading to hemolysis.
The aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
organism, reactive oxygen species can cause tissue damage affecting erythrocyte membranes leading to hemolysis.
The aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
I. paraguariensis. In living
organism, reactive oxygen species can cause tissue damage affecting erythrocyte membranes leading to hemolysis.
The aim of this work was to evaluate the protective effect of an aqueous extract of I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
I. paraguariensis (green
leaves) on the hemolysis of red blood cells induced by hydrogen peroxide and to correlate this activity with
the enzymatic activity related to hydrogen peroxide metabolism. The antioxidant activity of chlorogenic acid
and caffeine was also analysed to evaluate their contribution to the activity of the crude extract. The extract as
well as the isolated compounds protected red blood cells from hemolysis. This effect was related to a catalase-like
activity. This study could contribute to the knowledge of the antioxidant activity of I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.
I. paraguariensis in view of
the great quantities of yerba maté consumed by the population. Copyright © 2012 John Wiley & Sons, Ltd.