IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Vicenin-2, a Potential Anti-inflammatory Constituent of Urtica circularis.
Autor/es:
MARRASSINI, CARLA; DAVICINO, ROBERTO; ACEVEDO, CRISTINA; ANESINI, CLAUDIA; GORZALCZANY, SUSANA; FERRARO, GRACIELA
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2011 vol. 74 p. 1503 - 1507
ISSN:
0163-3864
Resumen:
Vicenin-2, a flavonoid glycoside, was isolated and identified from an ethanol extract of the aerial parts of Urtica circularis. This crude extract was found to possess significant anti-inflammatory activity in a carrageenan-induced rat hind paw edema model (41.5% inhibition at a dose of 300 mg/kg; ip). The effects of 1 on several inflammatory mediators were investigated. In cultured murine macrophages, this compound modified LPS-induced total nitrite and TNF-R production, in addition to the LPS-induced translocation of the nuclear factor NF-kB.
