IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
In vivo imunomodulatory effect of Tilia x viridis extracts on normal lymphocytes proliferation: a direct and indirect action
Autor/es:
ROBERTO DAVICINO; GABRIELA ZETTLER; MARGARITA RODRIGUEZ BRIZI; CARLA MARRASSINI; GRACIELA FERRARO; ROSANA FILIP; CLAUDIA ANESINI
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
JOHN WILEY & SONS LTD
Referencias:
Lugar: London; Año: 2011 vol. 25 p. 1342 - 1347
ISSN:
0951-418X
Resumen:
The flowers of Tilia species have been used in Europe for many years to treat colds, bronchitis, fever, inflammations and influenza. It is well known that lymphocytes play a role in acquired immunity related to pathogens and tumorous cells attached. The aim of this study was to determine the effect of an aqueous (AE) and a dichloromethane extract (DM) from Tilia x viridis which is widely used and distributed in Argentina, on normal murine lymphocyte proliferation after being administered in mice. Both extracts presented stimulatory effect on normal murine lymphocytes proliferation. The effect exerted by DM was principally related to macrophages activation meanwhile AE exerted an important direct effect on lymphocytes related to rutin presence. The stimulating effect, exerted on normal lymphocytes was due to a protective effect of apoptosis and also to cell IL2 production.
