IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Mill extracts and scopoletin (isolated compound): differential cell growth effects on lymphocytes .
Autor/es:
MARIA LAURA BARREIRO ARCOS, GRACIELA CREMASCHI, SILVIA WERNER, JORGE COUSSIO, GRACIELA FERRARO AND CLAUDIA ANESINI
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
InterScience Wiley
Referencias:
Lugar: Reino Unido; Año: 2006 vol. 20 p. 34 - 40
ISSN:
0951-418X
Resumen:
Aqueous extracts or infusions obtained from flowers of Tilia species are widely used for treatment of anxiety in folk medicine. In this work, the antiproliferative action of aqueous, dichloromethane and ethanol extracts obtained from Tilia cordata Mill. flowers on tumoral (BW 5147 lymphoma) and normal lymphocytes is described. Both extracts showed a selective action on tumoral cells, inducing apoptosis. In the case of normal T cells these extracts suppressed mitogen-induced proliferation without affecting viability, suggesting a suppressive but not cytotoxic effect. These effects were in a clearly concentration dependent. A coumarin (scopoletin), the main component in the dichloromethane extract presented antiproliferative action on BW 5147 cells, suggesting that it may be at least partly responsible for the activity displayed by this extract.
