IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Evaluation of antinociceptive, antinflammatory activities and Phytochemical Analysis of Aerial Parts of Urtica urens L.
Autor/es:
MARRASSINI, CARLA; ACEVEDO, CRISTINA; MIÑO, JORGE; FERRARO, GRACIELA; GORZALCZANY. SUSANA
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
JOHN WILEY & SONS LTD
Referencias:
Año: 2010 p. 1807 - 1812
ISSN:
0951-418X
Resumen:
Abstract The antinociceptive and antiinflammatory activities of the ethanol extract of the aerial part of Urtica urens were determined by experimental animal models. U. urens extract was found to possess significant antinociceptive activity in chemically induced mouse pain models, and antiinflammatory activity on carrageenan-induced rat hind paw edema. No significant antinociceptive activity in thermally induced pain or topical antiinflammatory activity in mouse models was found in the conditions tested. These results suggest that the extract would behave as a non steroidal antiinflammatory drug. The major compound of the extract was determined as chlorogenic acid and could be partly responsible for this activity.
