IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Comparative study of Tilia x viridis extract and isolated compounds on the proliferation of two lymphoma cell lines
Autor/es:
PATRICIA MICUCCI; PAOLA DI LEO LIRA; GABRIELA ZETTLER; SEBASTIAN TURNER; GRACIELA FERRARO; ROBERTO DAVICINO; CLAUDIA ANESINI
Revista:
Molecular Medicinal Chemistry
Editorial:
INSTITUTO DE INVESTIGACIÓN DE LAS CIENCIAS EXACTAS FÍSICAS Y NATURALES
Referencias:
Lugar: Buenos Aires; Año: 2010 vol. 21 p. 53 - 59
ISSN:
1666-888X
Resumen:
Several lymphoma T cell lines differ in membrane superficial markers and do not respond to the same drugs and compounds. Tilia x viridis (Bayer) Simonk nothosubspecie moltkei (Dippel) Xifreda is a plant widely distributed in Argentina. The aim of this work was to study comparatively the effects of dichloromethane extract and isolated compounds on BW 5147 and on another T lymphoma cell line EL-4, evaluating principally proliferation and viability. On BW 5147 cells, dichloromethane extract exerted antiproliferative action, presented cytostatic effect at low concentrations and cytotoxic action at high concentrations. Monoterpenes exerted antiproliferative action being the most potent limonene; low concentrations of them were cytostatic and high concentrations were cytotoxic. On EL-4 lymphoma, dichloromethane extract and monoterpenes exerted proliferative action, and none of them affected cell viability. It is extremely important to note that depending on tumor cell type the same extract or compounds can elicit different actions.
