IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
In vitro antiviral activity of nordihydroguayretic acid and its tetramethylated derivative on Arbovirus with medical-veterinary importance
Autor/es:
AGUILAR J; KONIGHEIM BS; MARTINEZ F; NUÑEZ MONTOYA SC; CONTIGIANI M
Lugar:
Mar del Plata
Reunión:
Otro; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIA SAIC SAFE SAB SAP AACYTAL NANOMED-AR HCS.; 2019
Institución organizadora:
Sociedades de Biociencia
Resumen:
In the search for new antiviral agents from native plant species, we began studying Larrea divaricata CAV. (Zigophyllaceae) and its main metabolite: nordihydroguaiaretic acid (NDGA). The antiviral effect of NDGA and its derivatives has been reported in numerous studies, the range of viruses evaluated is wide. However, there are few reports on arboviruses. We aimed to evaluate the in vitro effect of NDGA and its tetra methylated derivative, NDGA-4-M, on arbovirus: Chikungunya (CHIKV), St. Louis encephalitis (SLEV), Bunyamwera (BUNV) and Dengue types 1 and 4 (DENV-1, DENV-4), trying to establish the stages of the viral replication cycle affected.
