Validation of kinetic modeling of progesterone release from polymeric membranes

VILLEGAS, MERCEDES; GONZO, ELIO EMILIO; ROMERO, ANALIA IRMA; CID, ALICIA GRACIELA; BERMÚDEZ, JOSÉ MARÍA; PARENTIS, MÓNICA LILIANA

Asian Journal of Pharmaceutical Sciences

ELSEVIER

Año: 2017 p. 54 - 62

1818-0876

Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to 21 elucidate the physical transport mechanisms involved. In this paper we validate a novel 22 mathematical model that describes progesterone (Prg) controlled release from poly-3- 23 hydroxybutyric acid (PHB) membranes. A statistical analysis was conducted to compare 24 the fitting of our model with six different models and the Akaike information criterion 25 (AIC) was used to find the equation with best-fit. A simple relation between mass and 26 drug released rate was found, which allows predicting the effect of Prg loads on the 27 release behavior. Our proposed model was the one with minimum AIC value, and 28 therefore it was the one that statistically fitted better the experimental data obtained for 29 all the Prg loads tested. Furthermore, the initial release rate was calculated and 30 therefore, the interface mass transfer coefficient estimated and the equilibrium 31 distribution constant of Prg between the PHB and the release medium was also 32 determined. The results lead us to conclude that our proposed model is the one which 33 best fits the experimental data and can be successfully used to describe Prg drug release 34 in PHB membranes.