Optimization of 3D printing parameters for obtaining polyesterurethane scaffolds for tissue engineering

NAYLA J. LORES; PABLO C. CARACCIOLO; MARIANO H. TALOU ; XAVIER HUNG; GUSTAVO A. ABRAHAM

Porto Alegre

Workshop; 1st TERMIS AM Workshop; 2018

Termis

INTRODUCTIONIn recent years 3D printing technologies have gained the attention of researchers specialized in tissue engineering (TE). The mean role of 3D printing in TE is to provide a microenvironment that mimics the intricate properties of the native extracellular matrix (ECM), favoring the infiltration of seeded cells and conducting to the generation of a specific tissue. Moreover, 3D printing technologies must be able to yield quality scaffolds with controlled pore size, interconnectivity, adequate mechanical strength, biodegradability, and the ability to support cellular growth. Fused deposition modelling (FDM) is one of the most common 3D printing methods to fabricate structures with controlled internal and external geometry layer-by-layer using computer-aided design (CAD).OBJECTIVESFabricate bioresorbable scaffolds by FDM using filaments obtained by extrusion of segmented polyesterurethanes (SPU).