Electrospun fibers of poly(cyclodextrins) for antifungal treatment

A. COSTOYA ; F. MONTINI BALLARIN; G.A. ABRAHAM; C. ALVAREZ-LORENZO; A. CONCHEIRO

Lille

Conferencia; 4th European Conference on Cyclodextrins; 2015

European Cyclodextrin Society - Societé Française des Cyclodextrines

Electrospun fibers are very versatile platforms for a wide variety of applications. They have been extensively explored for drug delivery because of their high loading capacity and high encapsulation efficiency, from small molecules like antibiotics or anticancer agents to proteins, DNA and RNA [1]. Their composition and microstructure can be easily tuned to face up to diverse therapeutic demands. Natural cyclodextrins (CDs) and their derivatives have been used as components of electrospun fibers, solely or mixed with polymers, to facilitate the release of hydrophobic drugs [2]. However, the hydrophilic character of CDs may lead to a rapid disintegration of the fibers in contact with water. The aim of this work was to implement an electrospinning procedure to obtain fibers from polyCDs as a way to endow the fibers with affinity-controlled drug loading and release. PolyaCD and polybCD were prepared via cross-linking with epichlorohydrin (EPI) as water-soluble long molecular weight polymers [3]. Then, polyCDs forming complexes with fluconazole were mixed with poly(e-caprolactone) or poly(N-vinylpyrrolidone) for electrospinning. Obtained fibers showed a random distribution and diameters in the 400-800 nm range. They exhibited good thermal stability and sustained fluconazole release for several hours.