IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A one-pot microwaves-mediated approach towards 3- methylisoquinolines from hydrazone-derived 1-azatrienes
Autor/es:
TEODORO S. KAUFMAN; DIDIER F. VARGAS; ENRIQUE L. LARGHI
Lugar:
Santiago de Compostela
Reunión:
Conferencia; The 22nd International Electronic Conference on Synthetic Organic Chemistry (ECSOC-22); 2018
Institución organizadora:
MDPI
Resumen:
The use of hydrazone-type 1-azatriene derivatives for the synthesis of 3-methyl isoquinolines through a one pot microwave-assisted cyclization was developed and evaluated. The 1-azatrienes were generated by reaction of 2-propenylbenzaldehydes with hydrazines. Their subsequent electrocyclization gave rise to 3-methylisoquinolines, as well as to 3-methyl-3,4-dihydroisoquinolines as reaction by-products. The reaction conditions were optimized, and its scope and limitations were explored.
