MUTAGENIC AND PHYTOTOXIC STUDIES WITH COBALT COMPLEXES OF SULFA DRUGS

GIULIDORI, CECILIA; PONTORIERO, A.; MONTI, L.; MOSCONI, N.; HURE, E.; RIZZOTTO, M.

Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

Congreso; 1ª Reunión Internacional de Ciencias Farmacéuticas; 2010

Universidad Nacional de Córdoba, Universidad Nacional de Rosario

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-fareast-language:EN-US;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> The synthesis of metal sulfanilamide compounds had received much attention because sulfanilamides were the first effective chemotherapeutic agents for the prevention and cure of bacterial infections in humans. In this paper we analyzed the direct mutagenicity of two cobalt complexes of sulfa drugs: [CoII(PST)(H2O)4]·2H2O (Co(II)-PST; PST: phthalylsulfathiazolate) and [CoIII(ST)2OH(H2O)3] (Co(III)-ST; ST: sulfathiazolate), which exhibited moderately antifungal activity and antibacterial activity similar to the parent sulfonamides, and the phytotoxicity of Co(II)-PST. Both complexes did not show direct mutagenicity with the Ames test in the tested range. With the Allium test the behavior of Co(II)-PST was similar to phthalylsulfathiazole, its parent sulfonamide.