Preparation, Characterization and Dissolution Studies of Fast Release Diclofenac Sodium Tablets from PVP Solid Dispersions.

LAMAS, M.C.; LEONARDI D.; LAMBRI, O.; BASSANI, G.; BARRERA, M.G.; BOLMARO, R.; SALOMON C.J

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

TAYLOR & FRANCIS INC

Lugar: New York; Año: 2010 vol. 15 p. 162 - 168

1083-7450

Diclofenac sodium is a non steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analysed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.