Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

CALAMITA, GIUSEPPE; DONNINI, SANDRA; TAMMA, GRAZIA; MARINO, ANGELA; VALENTI, GIOVANNA; MARINELLI, RAUL A.; GROSSINI, ELENA

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

LANDES BIOSCIENCE

Lugar: Austin, Texas; Año: 2018 vol. 2018 p. 1 - 14

1942-0900

Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiologicaland biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controllingpleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover,increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty,hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providingnovel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This reviewfocuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membranetransport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology andpathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant actionon AQPs are also reviewed.