IFISE   05411
INSTITUTO DE FISIOLOGIA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
The Interactions between the Chronic Exposure to Aluminum and Liver Regeneration on Bile Flow and Organic Anion Transport in Rats
Autor/es:
GONZÁLEZ, M.; BERNAL, C.A.; MAHIEU, S.; CARRILLO, M.C.
Revista:
BIOLOGICAL TRACE ELEMENT RESEARCH
Referencias:
Año: 2008 vol. 127 p. 164 - 176
ISSN:
0163-4984
Resumen:
The chronic exposure to Aluminum (Al) may compromise different liver
functions, mainly during the hepatic regeneration. The aim of this
study is to investigate the interactions between the chronic i.p.
exposure to Al and hepatic regeneration (HR) on bile flow and organic
anion transport in experimental animals. For this purpose, we studied
bile flow and fractional transfer rates for the transport of hepatic
organic anions (hepatic uptake, sinusoidal efflux, and canalicular
excretion), as well as parameters related with the oxidative stress
(OS), on rats chronically treated with Al at 0 and 2 days of HR. The Al
treatment and time of HR caused a decrease in the biliary flow and in
the hepatic uptake and canalicular excretion constants. In addition, Al
and HR increased the lipoperoxidation associated with a reduction of
the glutathione content and glutathione peroxidase and catalase
enzyme's activities. Since the effects of Al and HR on biliary flow and
transport systems were additive, but not on the oxidative status,
different mechanisms might be involved on these alterations. Even
though the OS may play a key role on the hepatic deleterious effects,
there is no unique cause-effect relationship between OS and liver
dysfunction in this experimental animal model.